PUBLICAÇÕES INCT 2014

Publicações Internacionais

1. Pereira SL, Kummerle AE, Fraga CA, Barreiro EJ, Sudo RT, Zapata-Sudo G. N-Acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle. Life Sciences (1973), v. 94, p. 30-36, 2014. [DOI]

2.   Lacerda RB, Sales NM, da Siulva LL, Tesch R, Miranda ALP, Barreiro E J, Fernandes, PD, Fraga, CAM. Novel Potent Imidazo[1,2-a]pyridine-N-Glycinyl-Hydrazone Inhibitors of TNF-α Production: In Vitro and In Vivo Studies. Plos One, v. 9, p. e91660, 2014. [DOI]

3. Lima CKF, Silva RM, Lacerda RB, Santos BLR, Silva RV, Amaral LS, Quintas LEM, Fraga CAM, Barreiro EJ, Guimaraes MZP, Miranda ALP. LASSBio-1135: A Dual TRPV1 Antagonist and Anti-TNF-Alpha Compound Orally Effective in Models of Inflammatory and Neuropathic Pain. Plos One, v. 9, p. e99510, 2014. [DOI]

4. da Silva RB, da Silva EF, Carvalho AS, Fraga CA, Wardell SMSV, Wardell JL . Crystal structures of 1-hydroxylimidazole and imidazole 1-oxide derivatives. Zeitschrift für Kristallographie, v. 229, p. 709-722, 2014. [LINK]

5. Maia RC, Tesch R, Fraga CA. Acylhydrazone derivatives: a patent review. Expert Opinion on Therapeutic Patents, v. 24, p. 1161-1170, 2014. [DOI]

6. Sato JAP, Costa FN, Da Rocha MD, Barreiro EJ, Fraga CA, Punzo F, Ferreira FF. Structural characterization of LASSBio-1289: A novel vasoactive N-methyl-N-acylhydrazone derivative. CrystEngComm (Cambridge. Online), v. 17, p. 165-173, 2015.  [DOI]

7. Carvalho AS, Kaiser M, Brun R, Silva EF, Fraga CA. Antiprotozoal Activity of (E)-Cinnamic N-Acylhydrazone Derivatives. Molecules (Basel. Online), v. 19, p. 20374-20381, 2014. [DOI]

8. Pereira SL,  Kummerle AE,  Fraga CA,  Barreiro EJ,  Sudo RT,  Zapata-Sudo G. Vasodilator and antihypertensive effects of a novel N -acylhydrazone derivative mediated by the inhibition of L-type Ca 2+ channels. Fundamental & Clinical Pharmacology, v. 28, p. 29-41, 2014. [DOI]

9. Barbosa MLC, Lima LM, Tesch R,  Sant'Anna CMR,  Totzke F, Kubbutat  MHG,  Schachtele C, Laufer SA, Barreiro EJ. Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors. European Journal of Medicinal Chemistry, v. 71, p. 1-14, 2014.  [DOI]

10. Costa FN, Braz D, Ferreira FF, da Silva TF, Barreiro EJ, Lima LM, Colaço MV, Kuplich L, Barroso RC. Synchrotron X-ray powder diffraction data of LASSBio-1515: A new N-acylhydrazone derivative compound. Radiation Physics and Chemistry (1993), v. 95, p. 292-295, 2014. [DOI]

11. Amaral DN, Cavalcanti BC, Bezerra DP, Ferreira PMP, Castro RP, Sabino JR, Machado CML, Chammas R, Pessoa C, Sant’anna CMR, Barreiro EJ, Lima LM. Docking, Synthesis and Antiproliferative Activity of N-Acylhydrazone Derivatives Designed as Combretastatin A4 Analogues. Plos One, v. 9, p. e85380, 2014.

12. Alencar AK,  Pereira SL,  da Silva FE,  Mendes LV,  Cunha Vdo M,  Lima LM,  Montagnoli TL,  Caruso-Neves C, Ferraz EB,  Tesch R,  Nascimento JH, Sant'anna CMR, Fraga CA, Barreiro EJ,  Sudo RT , Zapata-Sudo G. N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity. International Journal of Cardiology (Print), v. 173, p. 154, 2014. [DOI]

13. da Silva YK,  Reyes CT,  Rivera G, Alves MA, Barreiro EJ, Alexandre-Moreira MS, Lima LM. 3-Aminothiophene-2-Acylhydrazones: Non-Toxic, Analgesic and Anti-Inflammatory Lead-Candidates. Molecules (Basel. Online), v. 19, p. 8456-8471, 2014. [DOI]

14. Nunes IKC, Tinoco LW, Martins HJ, Rezende C, Barreiro EJ, Lima LM.  In Vitro Microsomal Hepatic Metabolism of Antiasthmatic Prototype LASSBio-448. Current Topics in Medicinal Chemistry (Print), v. 14, p. 1388-1398, 2014. [DOI]

 15. Lima LM, Trachez MM, de Araújo JSC, da Silva JC, Amaral DN, Sudo RT, Barreiro EJ, Zapata-Sudo G. Novel Partial Agonist of PPAR-Gamma for Treatment of Diabetic Neuropathy in Rats. Journal of Diabetes & Metabolism, v. 05, p. 392-396, 2014. [DOI]

16. Araújo GL, Vieira AE, Barreiro EJ, Lima LM, Cardoso CN, Emiliano NF, Martins MT, Souza SS, de Souza AM, Berto C Jr, Costa ML, Campos LM, França FD, Tagliati CA. Toxicological in vitro and subchronic evaluation of LASSBio-596. Food and Chemical Toxicology, v. 73, p. 148-156, 2014. [DOI]

17. Carvalho GMC, Oliveira VR, Gomes MDM, Casquilho NV , Araujo AP, Soares RM , Azevedo SO, Monteiro APT , Claudio Canetti C , Lima LM , Barreiro EJ,  Zin WA . Pulmonary And Hepatic Injuries Caused By The Subchronic Exposure To Microcystin-lr: Role Of The Duration Of Treatment With LASSBio 596. Seminars in Respiratory and Critical Care Medicine, v. 189, p. A5023-A5023, 2014. [LINK]

18. Sampaio TS, Lima LM, Zardo RS, Pessoa C, Cavalcanti BC, Castro RP, Sabino JR, Fernandes PD, Barreiro EJ. Synthesis, Antiproliferative and Anti-inflammatory Activities of Novel Simplified Imatinib Analogues. Medicinal Chemistry, v. 4, p. 756-762, 2014. [DOI]

19. Chagas-Silva F, Nascimento-Viana JB, Romeiro LAS, Barberato LC, Noël F, Silva CLM. Pharmacological characterization of N1-(2-methoxyphenyl)-N4-hexylpiperazine as a multi-target antagonist of α1A/α1D-adrenoceptors and 5-HT1A receptors that blocks prostate contraction and cell growth. Naunyn-Schmiedeberg's Archives of Pharmacology, v. 387, p. 225-234, 2014. [DOI]

20. Noël F, Pompeu TET,  Moura,  BC. Functional binding assays for estimation of the intrinsic efficacy of ligands at the 5-HT1A receptor: Application for screening drug candidates. Journal of Pharmacological and Toxicological Methods, v. 70, p. 12-18, 2014. [DOI]

21. Stolz ED, Müller LG, Antonio CB, da Costa PF, Von Poser GL, Noël F, Rates SMK. Determination of pharmacological interactions of uliginosin B, a natural phloroglucinol derivative, with amitriptyline, clonidine and morphine by isobolographic analysis. Phytomedicine (Stuttgart), v. 21, p. 1684-1688, 2014. [DOI]

22. Rocha SC, Pessoa MTC, Neves LDR, Alves SLG, Silva LM, Santos HL, Oliveira SMF,  Taranto AG, Comar M, Gomes IV, Santos FV,  Paixão N,  Quintas LEM, Noël F, Pereira AF, , Tessis ACSC, , Gomes NLS,  Moreira OC,  Rincon-Heredia RK,  Varotti FP,  Blanco G, Villar JAPF, Contreras RG,  Barbosa LA. 21-Benzylidene Digoxin: A Proapoptotic Cardenolide of Cancer Cells That Up-Regulates Na,K-ATPase and Epithelial Tight Junctions. Plos One, v. 9, p. e108776, 2014. [DOI]

23. Cavalcante-Silva LHA, Falcão MAP, Vieira ACS, Viana MDM, de Araújo-Júnior JX, Sousa JCF, da Silva TMS, Barbosa-Filho JM,  Noël F,  de Miranda GEC, de Oliveira Santos BV, Alexandre-Moreira MS.  Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine. Molecules (Basel. Online), v. 19, p. 14699-14709, 2014. [DOI]

24.  Zapata-Sudo G, da Silva JS, Pereira SL,  Souza PJC,  de Moura RS, Sudo RT.    Oral treatment with Euterpe oleracea Mart. (açaí) extract improves cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction. BMC Complementary and Alternative Medicine (Online), v. 14, p. 227, 2014. [DOI]

25. Debom RC, Trachez MM, Zapata-Sudo G, da Silva JS, Oliveira KM, Garcia AL, Godoy LM, Pacheco PC, Sudo RT. Novel Nicotinic Receptor Agonist Reduces Hyperalgesia and Allodynia of Neuropathic Pain in Diabetic Rats. Journal of Diabetes & Metabolism, v. 5, p. 396, 2014. [DOI]

26. Zapata-Sudo G, Sudo SZ, Alencar AKN, Sudo RT. Targeting of the Adenosine Receptors as a Novel Strategy for the Treatment of Arterial Hypertension. Journal of Neurology and Neurophysiology, v. 5, p. 243, 2014. [LINK]

27. Alencar AKN, Barreiro EJ, Sudo RT, Zapata-Sudo G. Adenosine A2A Receptor as a Target of Treatment for Pulmonary Arterial Hypertension. Clinical Research in Pulmonology, v. 2, p. 1021, 2014. [LINK]

28.  de Oliveira GP, Silva JD, de Araújo CC,  Prota LFM, Abreu SC,  Madeira C,  Morales MM,  Takiya CM,  Diaz BL,  Capelozzi VL, Panizzutti R, Pelosi P, Rocco PRM. Intravenous Glutamine Administration Reduces Lung and Distal Organ Injury in Malnourished Rats With Sepsis. Shock, v. 41, p. 222 - 232, 2014. [DOI]

29. Saddy F, Sutherasan Y, Rocco PR, Pelosi P. Ventilator-Associated Lung Injury during Assisted Mechanical Ventilation. Seminars in Respiratory and Critical Care Medicine, v. 35, p. 409-417, 2014. [DOI]

30. Silva JD, Paredes BD, Araújo IM, Lopes-Pacheco M, Oliveira MV, Suhett GD, Faccioli LA, Assis E, Castro-Faria-Neto HC, Goldenberg RC, Capelozzi VL, Morales MM, Pelosi P, Xisto DG, Rocco PRM. Effects of bone marrow derived mononuclear cells from healthy or acute respiratory distress syndrome donors on recipient lung-injured mice. Critical Care Medicine, v. 42, p. e510-524, 2014.[DOI]

31. Burburan SM, Silva JD, Abreu SC, Samary CS, Guimarães IH, Xisto DG, Morales MM, Rocco PRM. Effects of inhalational anaesthetics in experimental allergic asthma. Anaesthesia (London. Print), v. 6, p. 573-582, 2014. [DOI]

32. Elias ASNT, Oliveira GP,  Ornellas DS,  Morales MM, Capelozzi VL, Haddad R, Pelosi P, Rocco PRM, Garcia CSNB. Effects of early and late pneumothorax drainage on the development of pulmonary oedema. Respiratory Physiology & Neurobiology, v. 195, p. 27-36, 2014. [DOI]

33. Krebs J, Tsagogiorgas C, Pelosi P,  Rocco PRM,  Hottenrott M , Sticht C , Yard B,  Luecke T. Open lung approach with low tidal volume mechanical ventilation attenuates lung injury in rats with massive brain damage. Critical Care (London. Print), v. 18, p. R59, 2014. [DOI]

34. da Silva AL, Martini SV, Abreu SC,  Samary CDS, Diaz BL,  Fernezlian S, de Sá VK,  Capelozzi VL,  Boylan NJ, Goya RG,  Suk, JS, Rocco PRM,  Hanes J,  Morales MM.  DNA nanoparticle-mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma. Journal of Controlled Release, v. 180, p. 125-133, 2014. [DOI]

35. Uhlig C, Silva PL, Ornellas D,  Santos RS, MirandaPJ,  Spieth PM,  Kiss T,  Kasper M,  Wiedemann B, Koch T,  Morales MM,  Pelosi P, de Abreu MG, Rocco PRM. The effects of salbutamol on epithelial ion channels depend on the etiology of acute respiratory distress syndrome but not the route of administration. Respiratory Research (Print), v. 15, p. 56, 2014. [DOI]

36. Santos CL, Moraes L, Santos RS, dos Santos SC, Silva JD, Morales MM, Capelozzi VL, de Abreu MG, Schanaider A, Silva PL, Garcia CSNB, Pelosi P, Rocco PRM. The biological effects of higher and lower positive end-expiratory pressure in pulmonary and extrapulmonary acute lung injury with intra-abdominal hypertension. Critical Care (London. Print), v. 18, p. R121, 2014. [DOI]

37. Antunes MA, Laffey JG, Pelosi P, Rocco PRM.  Mesenchymal Stem Cell Trials for Pulmonary Diseases. Journal of Cellular Biochemistry (Print), v. 115, p. 1023-1032, 2014. [DOI]

38. Silva PL, Pelosi P, Rocco PRM. Fluids in acute respiratory distress syndrome. Current Opinion in Critical Care, v. 20, p. 104-112, 2014. [DOI]

 39. Martini SV, da Silva AL, Ferreira D,  Gomes K,  Ornellas FM,  Lopes-Pacheco M,  Zin E,  Petrs-Silva H,  Rocco PRM, Morales MM. Single Tyrosine Mutation in AAV8 Vector Capsid Enhances Gene Lung Delivery and Does Not Alter Lung Morphofunction in Mice. Cellular Physiology and Biochemistry (Online), v. 34, p. 681-690, 2014. [DOI]

40. Moraes L, Santos CL, Santos RS, Cruz FF, Saddy F, Morales MM,  Capelozzi VL,  Silva PL, de Abreu MG , Garcia CSNB,  Pelosi P, Rocco PRM. Effects of sigh during pressure control and pressure support ventilation in pulmonary and extrapulmonary mild acute lung injury. Critical Care (London. Print), v. 18, p. 474, 2014. [DOI]

41. Rodríguez-González R, Ramos-Nuez Á, Martín-Barrasa JL, López-Aguilar J, Baluja A, Álvarez J, Rocco PRM, Pelosi P, Villar J. Endotoxin-induced lung alveolar cell injury causes brain cell damage. Experimental Biology and Medicine (Maywood, N.J.: Print), v. 240, p. 135-142, 2014. [DOI]

42. Abreu SC, Antunes MA,  Mendonça L,  Branco VC, de Melo EB,  Olsen PC, Diaz BL,  Weiss DJ,  Paredes BD , Xisto DG,  Morales MM,  Rocco PRM. Effects of bone marrow mononuclear cells from healthy or ovalbumin-induced lung inflammation donors on recipient allergic asthma mice. Stem Cell Research & Therapy, v. 5, p. 108-108, 2014. [DOI]

43. Spieth PM, Silva PL,  Garcia CSNB,  Ornellas DS,  Samary CS,  Moraes L,  Bentes M,  Morales MM, Kasper M,  Güldner A,  Huhle R,  Koch T,  Pelosi P, de Abreu  MG,  Rocco PRM. Modulation of Stress versus Time Product during Mechanical Ventilation Influences Inflammation as Well as Alveolar Epithelial and Endothelial Response in Rats. Anesthesiology (Philadelphia), v. 122, p. 106-116, 2014. [DOI]

44. Carvalho NC, Güldner A, Beda A, Rentzsch I, Uhlig C, Dittrich S, Spieth PM, Wiedemann B, Kasper M, Koch T, Richter T, Rocco PRM, Pelosi P, de Abreu MG. Higher Levels of Spontaneous Breathing Reduce Lung Injury in Experimental Moderate Acute Respiratory Distress Syndrome. Critical Care Medicine, v. 42, p. e702-715, 2014.  [DOI]

45. Carvalho GM, Nagato LK, Fagundes Sda S, Dos Santos FB, Calheiros AS, Malm O, Bozza PT, Saldiva PH, Faffe DS, Rocco PRM, Zin WA. Time course of pulmonary burden in mice exposed to residual oil fly ash. Frontiers in Physiology, v. 5, p. 366-366, 2014. [LINK]

46. Kuhl CP, Garcez TNA, Magrisso AB, Laurino CCFC, Cirne-Lima EO, Rocco PRM, Macedo-Neto AV.  Development of different degrees of elastase-induced emphysema in mice: a randomized controlled experimental study. Clinical and Biomedical Research, v. 34, p. 297-306, 2014. [LINK]

47. Nardelli L.M, Rzezinski A, Silva JD, Maron-Gutierrez T, Ornellas DS, Henriques LI, Capelozzi VL, Teodoro WR,  Morales MM,  Silva PL, Pelosi P, Garcia CSNB, Rocco PRM. Effects Of Acute Hypercapnia With And Without Acidosis On Lung Inflammation And Apoptosis In Experimental Acute Lung Injury. Respiratory Physiology & Neurobiology, v.205, p. 1- 6, 2014. [DOI]

48. Cavalcanti V, Santos CL, Samary CS, Araújo MN, Heil LBB, Morales MM, Silva PL, Pelosi P, Fernandes FC, Villela N,  Rocco PRM. Effects of short-term propofol and dexmedetomidine on pulmonary morphofunction and biological markers in experimental mild acute lung injury. Respiratory Physiology & Neurobiology, v. 203, p. 45-50, 2014. [DOI]

49. Antunes MA, Abreu SC, Cruz FF, Teixeira AC,  Lopes-Pacheco M,  Bandeira E, Olsen PC, Diaz BL, Takyia CM,  Freitas IPRG,  Rocha NN, Capelozzi VL, Xisto DG, Weiss DJ, Morales MM,  Rocco PRM. Effects of different mesenchymal stromal cell sources and delivery routes in experimental emphysema. Respiratory Research (Print), v. 15, p. 118, 2014. [DOI]

50. Lopes-Pacheco M, Ventura TG, de Oliveira HD, Monção-Ribeiro LC, Gutfilen B,  de Souza SAL, Rocco PRM,  Borojevic R,  Morales MM,  Takiya CM. Infusion of bone marrow mononuclear-cells reduces lung fibrosis but not inflammation in the late stages of murine silicosis. Plos One, v. 9, p. e109982, 2014. [DOI]

51. Lee JW, Rocco PRM, Pelosi P.  Mesenchymal Stem Cell Therapy for Acute Respiratory Distress Syndrome. Anesthesiology (Philadelphia), v. 122, p. 238-240, 2014. [DOI]

52. Pelosi P, Rocco PRM. To prevent or cure acute respiratory distress syndrome: That is the question! Current Opinion in Critical Care. v.20, p. 1-2, 2014. [DOI]

53. Maron-Gutierrez T, Laffey JG, Pelosi P, Rocco PRM. Cell-based therapies for the acute respiratory distress syndrome. Current Opinion in Critical Care, v.20, p. 122-131, 2014. [DOI]

54. Righetti RF,  Pigati PADS,  Possa SS,  , Habrum FC,  Xisto DG,  Antunes MA, , Leick EA,  Prado CM,  Martins MDA,  Rocco PRM,  Tibério IDFLC. Effects of Rho-kinase inhibition in lung tissue with chronic inflammation. Respiratory Physiology and Neurobiology, v. 192, p.134-146, 2014. [DOI]

55. Coelho-Cerqueira E, Netz PA, do Canto VP, Pinto AC, Follmer C. Beyond Topoisomerase Inhibition: Antitumor 1,4-Naphthoquinones as Potential Inhibitors of Human Monoamine Oxidase. Chemical Biology & Drug Design (Print), v. 83, p. 401-410, 2014. [DOI]

56. Martinez ST, Pinto AC, Glasnov T, Kappe CO. Chemistry of pyrrolizidine alkaloids revisited-semi-synthetic microwave and continuous-flow approaches toward Crotalaria-alkaloids. Tetrahedron Letters, v. 55, p. 4181-4184, 2014. [DOI]

57. Boechat N, Pinheiro LCS, Pinto AC, Silva TS, Waedell J, Wardell, SMSV. Crystal structures of two anhydrous and one hydrated 7-(arylamino)-5-methyl-2-(trifluoromethyl)-[1,2,4]-triazolo-[1,5-a]pyrimidine derivatives. Zeitschrift fur Kristallographie, v. 229, p. 459-471, 2014. [LINK]
 
58. Fierro IM, de Menezes Alencar MS, Lins Mendes FM, de Souza Mendes C, Nunes BF, Antunes AMS. Nanoparticles applied to antineoplastic agents: a patent landscape. Pharmaceutical Patent Analyst, v. 3, p. 613-623, 2014. [DOI]

59. Ribeiro-Filho J, Leite FC, Costa HF, Calheiros AS, Torres RC, de Azevedo CT, Martins MA, Dias CdaS, Bozza PT, Piuvezam MR. Curine inhibits mast cell-dependent responses in mice. Journal of Ethnopharmacology, v. 155, p. 1118-1124, 2014. [DOI]

60. Nihi F, Moreira D, Santos Lourenço AC, Gomes C, Araujo SL, Zaia RM, Trevisani NB, Pinto LD, Moura-Costa DD, de Morais RN, Paumgartten FJR, Martino-Andrade AJ. Testicular Effects Following In Utero Exposure to the Antivirals Acyclovir and Ganciclovir in Rats. Toxicological Sciences (Print), v. 139, p. 220-233, 2014. [DOI]

61. Hussin M, Siti Amrah S, Hasnan J, Paumgartten FJR. Evaluation on the reproductive performance and spontaneous malformations amongst SD rats in the Institute for Medical Research colony. Malaysian Journal of Veterinary Research, v.5, p. 53-63, 2014. [Link]

62. Paumgartten FJR, de Oliveira ACAX. The bisphenol A toxicological paradox: The more we learn the less we know for sure. Environmental Skeptics and Critics, v. 3, p. 65-82, 2014. [LINK]

63. Coelho DR, de Carvalho RR, Rocha RCC, Saint'Pierre TD, Paumgartten FJR. Effects of in utero and lactational exposure to SbV on rat neurobehavioral development and fertility. Reproductive Toxicology (Elmsford, N.Y.), v. 50, p. 98-107, 2014. [DOI]

64. Rocha MRE, de Souza JJ, Barcellos LT, Sant'Anna CMR, Braz-Filho R, Vieira IJC. A Novel 3, 9-(1,2,3-Trioxocine)-Type Steroid of Rauia nodosa (Rutaceae). Molecules (Basel. Online), v. 19, p. 14637-14648, 2014. [DOI]

65. de Magalhães CS, Almeida DM, Barbosa HJC, Dardenne LE. A dynamic niching genetic algorithm strategy for docking highly flexible ligands. Information Sciences, v. 289, p. 206-224, 2014. [DOI]

66. Custódio FL, Barbosa HJC, Dardenne LE. A multiple minima genetic algorithm for protein structure prediction. Applied Soft Computing (Print), v. 15, p. 88-99, 2014. [DOI]

67. Guedes IA, de Magalhães CS, Dardenne LE. Receptor-ligand molecular docking. Biophysical Reviews, v. 6, p. 75-87, 2014. [DOI]

68. Vieira AM, Neto EH, Figueiredo CC, Barja- Fidalgo C, Fierro IM, Morandi V. ATL-1, a synthetic analog of lipoxin, modulates endothelial permeability and interaction with tumor cells through a VEGF-dependent mechanism. Biochemical Pharmacology, v. 90, p. 388-396, 2014. [DOI]

69. Ribeiro-Pereira C, Moraes JA, Souza Mde J, Laurindo FR, Arruda MA, Barja-Fidalgo C. Redox modulation of FAK controls melanoma survival - Role of NOX4. Plos One, v. 9, p. e99481, 2014. [DOI]

70. Boa BCS,  Souza MGC, Leite RD,  da Silva SV,  Barja-Fidalgo TC, Kraemer-Aguiar LG,, Bouskela E. Chronic Aerobic Exercise Associated to Dietary Modification Improve Endothelial Function and eNOS Expression in High Fat Fed Hamsters. Plos One, v. 9, p. e102554, 2014. [DOI]
 
71. Bueno RV, Braga RC, Segretti ND,  Ferreira EI,  Trossini GHG, Andrade CH. New Tuberculostatic Agents Targeting Nucleic Acid Biosynthesis: Drug Design using QSAR Approaches. Current Pharmaceutical Design (Print), v. 20, p.4474-4485, 2014. [LINK]

72. Serafim RAM, Gonçalves JE, de Souza FP, Loureiro APM,  Storpirtis S, Krogh R,  Andricopulo AD,  Dias LC, Ferreira EI. Design, synthesis and biological evaluation of hybrid bioisoster derivatives of N-acylhydrazone and furoxan groups with potential and selective anti-Trypanosoma cruzi activity. European Journal of Medicinal Chemistry, v. 82, p. 418-425, 2014. [DOI]

73. Lima-Júnior RC, Freitas HC, Wong DV, Wanderley CW, Nunes LG, Leite LL, Miranda SP, Souza MH, Brito GA, Magalhães PJ, Teixeira MM, Cunha FQ, Ribeiro RA. Targeted Inhibition of Interleukin-18 Attenuates Irinotecan-Induced Intestinal Mucositis in Mice. British Journal of Pharmacology, v. 171, p. 2335 – 2350, 2014. [DOI]

74. Ferreira AE, Sisti F, Sônego F, Wang S, Filgueiras LR, Brandt S, Serezani AP, Du H, Cunha FQ, Alves-Filho JC, Serezani CH. PPAR- /IL-10 Axis Inhibits MyD88 Expression and Ameliorates Murine Polymicrobial Sepsis. Journal of Immunology, v. 192, p. 2357-2365, 2014. [DOI]

75. Guabiraba R, Besnard AG, Menezes GB, Secher T, Jabir MS, Amaral SS, Braun H, Lima-Junior RC, Ribeiro RA, Cunha FQ, Teixeira MM, Beyaert R, Graham GJ, Liew FY. IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice. Mucosal Immunology, v.7,p. 1079 – 1093, 2014. [DOI]

76.  Hernandes MS, D'Avila JC, Trevelin SC, Reis PA, Kinjo ER, Lopes LR, Castro-Faria-Neto HC, Cunha FQ, Britto LR, Bozza FA. The role of Nox2-derived ROS in the development of cognitive impairment after sepsis. Journal of Neuroinflammation, v. 11, p. 36-48, 2014. [DOI]

77. Vieira SM, Silva RL, Lemos HP, Amorim RC, Silva EC, Reinach PS, Cunha FQ, Pohlit AM, Cunha TM. Gastro-protective effects of isobrucein B, a quassinoid isolated from Picrolemma sprucei. Fitoterapia, v. 95, p. 8-15, 2014. [DOI]

78. de Aquino SG, Abdollahi-Roodsaz S, Koenders MI, van de Loo FA, Pruijn GJ, Marijnissen RJ, Walgreen B, Helsen MM, van den Bersselaar LA, de Molon RS, Avila Campos MJ, Cunha FQ, Cirelli JA, van den Berg WB. Periodontal Pathogens Directly Promote Autoimmune Experimental Arthritis by Inducing a TLR2- and IL-1-Driven Th17 Response. Journal of Immunology, v. 192, p. 4103 – 4111, 2014. [DOI]

79. Wanderley CW, Silva CM, Wong DV, Ximenes RM, Morelo DF, Cosker F, Aragão KS, Fernandes C, Palheta-Júnior RC, Havt A, Brito GA, Cunha FQ, Ribeiro RA, Lima-Júnior RC. Bothrops jararacussu snake venom-induces a local inflammatory response in a prostanoid- and neutrophil-dependent manner. Toxicon (Oxford), v. 90, p. 134 - 147, 2014. [DOI]

80. Saia RS, Mestriner FL, Bertozi G, Cunha FQ, Cárnio EC. Cholecystokinin Inhibits Inducible Nitric Oxide Synthase Expression by Lipopolysaccharide-Stimulated Peritoneal Macrophages. Mediators of Inflammation (Print), v. 2014, p. 1-14, 2014. [DOI]

81. Sônego F, Castanheira FVS, Czaikoski PG, Kanashiro A, Souto FO, França RO, Nascimento DC, Freitas A, Spiller F, Cunha LD, Zamboni DS, Alves-Filho JC, Cunha FQ. MyD88-, but Not Nod1- and/or Nod2-Deficient Mice, Show Increased Susceptibility to Polymicrobial Sepsis due to Impaired Local Inflammatory Response. Plos One, v. 9, e103734, 2014. [DOI]

82. Staurengo-Ferrari L, Zarpelon AC, Longhi-Balbinot DT, Marchesi M, Cunha TM, Alves-Filho JC, Cunha FQ, Ferreira SH, Casagrande R, Miranda KM, Verri WA Jr. Nitroxyl inhibits overt pain-like behavior in mice: Role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway. Pharmacological Reports, v. 66, p. 691-698, 2014. [DOI]

83. Barragán-Iglesias P, Rocha-González HI, Pineda-Farias JB, Murbartián J, Godínez-Chaparro B, Reinach PS, Cunha TM, Cunha FQ, Granados-Soto V. Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain. European Journal of Pharmacology, v. 738, p. 91-100, 2014. [DOI]

84. Sônego F, Alves-Filho JC, Cunha FQ. Targeting neutrophils in sepsis. Expert Review of Clinical Immunology, v. 10, p. 1019 - 1028, 2014. [DOI]

85. Borghi SM, Zarpelon AC, Pinho-Ribeiro FA, Cardoso RDR, Cunha TM, Alves-Filho JC, Ferreira SH, Cunha FQ, Casagrande R, Verri WA. Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice. Journal of Pharmacy and Pharmacology, v. 66, p. 1009-1020, 2014. [DOI]

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