PUBLICAÇÕES INCT 2015

Publicações Internacionais

1. Lima Toccafondo Vieira, Manuela; Lidia Moreira Lima; Barreiro, Eliezer J.; Tagliati, Carlos Alberto. Investigation of Low Bioavailability Using Physiologically Based Pharmacokinetic Modeling: A Case Example (Lassbio-596). British Journal of Applied Science & Technology, v.5, p. 613-620, 2015.
DOI: 10.9734/BJAST/2015/13527

2. Ferreira, Andrea; Franca, Flavia Dayrell; Tagliati, Carlos Alberto; Chaves, Miriam Martins. Cyclic adenosine monophosphate protects renal cell lines against amphotericin B toxicity in a PKA-independent manner. Drug and Chemical Toxicology (New York, N.Y. 1978), p.1-7, 2015.
DOI: 10.3109/01480545.2015.1012210

3. Gontijo, V. S.; Januario, J. P.; Judice, W. A. S.; Antunes, A. A.; Cabral, I. S. R.; Assis, D. M.; Juliano, M. A.; Campos, I.; Marques, M.J.; Viegas Junior, C.; dos Santos, M. H.. Morelloflavone and its semisynthetic derivatives as potential novel inhibitors of cysteine and serine proteases. Journal of Medicinal Plant Research, v. 9, p. 426-434, 2015.
Article Number: A42115152263, ISSN 1996-0875
DOI: 10.5897/JMPR2014.5641

4. Fernandes, I.A.; Almeida, L.; Ferreira, P. E.; Marques, M.J.; Rocha, R. P.; Leomil- Coelho, L. F.; Carvalho, D.T.; Viegas Jr., C.. Synthesis and biological evaluation of novel piperidine-benzodioxole derivatives designed as potential leishmanicidal drug candidates. Bioorganic & Medicinal Chemistry Letters (Print), v. 25, p. 3346-3349, 2015.
DOI: 10.1016/j.bmcl.2015.05.068

5. Almeida, L.; Alves, K. F.; Rezende, C.M.M.; Jesus, L. O. P.; Pires, F. R.; Viegas Jr., C.; Izidoro, M. A.; Judice, W. A. S.; dos Santos, M. H.; Marques, M. J.. Benzophenone derivatives as cysteine protease inhibitors and biological activity against Leishmania(L.) amazonensis amastigotes. Biomedicine & Pharmacotherapy, v. 75, p. 93-99, 2015.
DOI: 10.1016/j.biopha.2015.08.030

6. Moraes, Barbra Katyuscia Sanches; Bajerski, Lisiane; Parisoto, Alcides; Silva, Carlos Eduardo da Rosa; Alves, Marina Amaral; Barreiro, Eliezer J.; Freddo, Rodrigo José; Dalla Costa, Teresa; Lima, Lidia Moreira; Haas, Sandra Elisa. Simple HPLC-UV for the quantification of a new leishmanicidal candidate (E)-1-4 (trifluoromethyl) benzylidene) - 5 - (2-4-dichlorozoyl)carbonylhydrazine (LASSBio-1736) in rat plasma for pharmacokinetics assessment. Biomedical Chromatography, 2015

7. Marques, A. B.; Antunes, A. M. S.; Alves, F.C.; Maldonado, José Manoel S.V.. Competences for Innovation In Electromedical Equipment: A Brazilian Perspective. Business Management Review (BMR), v. 4, p. 691-703, 2015.

8. Carvalho, K. M.; Winter, E.; Antunes, A. M. S.. Evaluation of the Development of R&D into Parkinson's Disease through Technology Monitoring Using Patent Documents and Scientific Articles. International Journal of Research in Pharmacy and Biosciences, v. 2, p. 17-24, 2015.
http://www.ijrpb.org/pdf/v2-i3/4.pdf

9. Possas, Cristina; de Souza Antunes, Adelaide Maria; Mendes, Flavia Maria Lins; de Oliveira Rodrigues Schumacher, Suzanne; Martins, Reinaldo Menezes; Homma, Akira. Access to new technologies in multipatented vaccines: challenges for Brazil. Nature Biotechnology , v. 33, p. 599-603, 2015.
DOI: 10.1038/nbt.3244

10. Rodrigues Cezário, Wendel; Maria de Souza Antunes, Adelaide; Fernando Leite, Luiz; Pio Borges de Menezes, Rodrigo. The energy revolution in the USA and the pre-salt reserves in Brazil: Risks and opportunities for the Brazilian petrochemical industry. Futures (London), v. 73, p. 1-11, 2015.
DOI: 10.1016/j.futures.2015.07.013

11. Antunes, A. M. S.; Kropf F, M.. Technology Foresight of New Orthopedic Prostheses: Trends in Innovation and Development in Health. HNTMB, v. 2, p. 2-6, 2015.
http://www.heraldopenaccess.us/fulltext/Nanotechnology-Nanomedicine-&-Nanobiotechnology/Technology-Foresight-of-New-Orthopedic-Prostheses-Trends-in-Innovation-and-Development-in-Health.pdf

12. Antunes, A. M. S.; Parreiras, V. M. A.. Technological Prospection on Nanotechnologies Applied to the Petroleum Industry. Recent Patents on Nanotechnology, v. 2, p. 106-113, 2015.
DOI: 10.2174/187221050902150819152708

13. Carvalho, Karinne Marieta; Winter, Eduardo; Souza Antunes, Adelaide Maria de. Analysis of Technological Developments in the Treatment of Alzheimer’s Disease through Patent Documents. Intelligent Information Management, v. 07, p. 268-281, 2015.
DOI: 10.4236/iim.2015.75022

14. De- Oliveira, Ana C. A. X.; Poça Kátia S.; Totino, Paulo R. R.; Paumgartten, Francisco J. R.. Modulation of Cytochrome P450 2A5 Activity by Lipopolysaccharide: Low-Dose Effects and Non-Monotonic Dose-Response Relationship. PlosOne, v.10, p. e0117842, 2015.
DOI: 10.1371/journal.pone.0117842

15. Mello, Marcia S. Campos; Delgado, Isabella F.; Favareto, Ana Paula A.; Lopes, Camila M.T.; Batista, Marcelo M.; Kempinas, Wilma de-Grava; Paumgartten, Francisco J.R.. Sexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periods. Toxicology Reports, v. 2, p. 405-414, 2015.
DOI:10.1016/j.toxrep.2014.12.006

16. Paumgartten, Francisco José Roma; Commentary: Estrogenic and Anti-Androgenic Endocrine Disrupting Chemicals and Their Impact on the Male Reproductive System. Frontiers in Public Health, v. 3, p.165, 2015.
DOI:10.3389/fpubh.2015.00165

17. Solecki, Roland; Rauch M; Gall, A.; Buschmann, J.; Clark, Ruth; Fuchs, A.; Kan, H.; Heinrich, Verena; Kellner, R.; Knudsen, Thomas B.; Li, W ; Makris, Susan; Ooshima, Y.; Paumgartten, F; Priesma, A. H.; Schoenfelder, Gilbert; Oelgeschlaeger, M.; Schaefer, C.; Shiota, Kohei; Ulbrich, B.; Ding, X.; Chahoud, I. Continuing harmonization of terminology and innovations for methodologies in developmental toxicology: Report of the 8th Berlin Workshop on Developmental Toxicity, 14-16 May 2014. Reproductive Toxicology (Elmsford, N.Y.), v. 57, p. 140-146, 2015.
DOI: 10.1016/j.reprotox.2015.06.046

18. Paumgartten, Francisco José Roma; Letter to the Editor: DDT Exposure In Utero and Breast Cancer. The Journal of Clinical Endocrinology and Metabolism, v. 100, p. L104-L105, 2015.
DOI: 10.1210/jc.2015-3243

19. Pinto, Flávia Cristina Morone; de-Oliveira, Ana Cecília A. X.; de-Carvalho, Rosangela R.; Gomes- Carneiro, Maria Regina; Coelho, Deise R; Lima, Salvador Vilar C.; Paumgartten, Francisco José R.; Aguiar, José Lamartine A.. Acute Toxicity, Cytotoxicity, Genotoxicity and Antigenotoxic Effects of a Cellulosic Exopolysaccharide Obtained From Sugarcane Molasses. Carbohydrate Polymers, vol. 137, p. 556–560, 2015.
doi:10.1016/j.carbpol.2015.10.071

20. Priscila V.S.Z. Capriles; Luiz Phillippe R. Baptista; Isabella A. Guedesa; Ana Carolina R. Guimarães; Fabio L. Custódio; Marcelo Alves-Ferreira; Laurent E. Dardenne. Structural modeling and docking studies of ribose 5-phosphate isomerase from Leishmania major and Homo sapiens: A comparative analysis for Leishmaniasis treatment. Journal of Molecular Graphics and Modelling. v. 55, p. 134–147, 2015
DOI:10.1016/j.jmgm.2014.11.002

21. Da Matta, Carolina Barbosa Brito; De Queiroz, Aline Cavalcanti; Santos, Mariana Silva; Gonçalves, Vinicius Tomaz; Cistia, Catarina de Nigris Del; Alexandre-Moreira, Magna Suzana; Sant’Anna, Carlos Mauricio R.; DaCosta, João Batista N. Novel Dialkylphosphorilhydrazones: Synthesis, Leishmanicidal Evaluation and Theoretical Investigation of the Proposed Mechanism of Action. European Journal of Medicinal Chemistry, v.101, p. 1-12, 2015.
DOI:10.1016/j.ejmech.2015.06.014

22. Melos, Jorge Luiz R.; Torres- Santos, Eduardo Caio, Faiões, Viviane dos S.; Cistia, Catarina de Nigris Del; Sant’anna, Carlos Maurício R.; Rodrigues- Santos, Cláudio Eduardo; Echevarria, Aurea. Novel 3,4-methylenedioxyde-6-X-benzaldehyde-thiosemicarbazones: synthesis and antileishmanial effects against Leishmania amazonensis. European Journal of Medicinal Chemistry, v. 103, p. 409-417, 2015.
DOI:10.1016/j.ejmech.2015.09.009 

23. Rodrigues- Santos, Cláudio; Echevarria, Aurea; Sant’anna, Carlos Mauricio R.; Bitencourt, Thiago; Nascimento, Maria; Bauerfeldt, Glauco. Quantitative Structure-Property Relationship (QSPR) Models for a Local Quantum Descriptor: Investigation of the 4- and 3-Substituted-Cinnamic Acid Esterification. Molecules (Basel. Online), v. 20, p. 17493-17510, 2015.
DOI: 10.3390/molecules200917493.

24. Florentino, Iziara F.; Galdino, Pablinny M.; Oliveira, Lanussy P.; Silva, Daiany P. B.; Pazini, Francine; Vanderlinde, Frederico A.; Lião, Luciano M.; Menegatti, Ricardo; Costa, Elson A. Involvement of the NO/cGMP/KATP pathway in the antinociceptive effect of the new pyrazole 5-(1-(3-fluorophenyl)-1H-pyrazol-4-yl)-2H-tetrazole (LQFM-021). Nitric Oxide, v. 47, p. 17-24, 2015.
DOI:10.1016/j.niox.2015.02.146

25. Pompeu, Thais E.T.; Monte, Fernando M.; Bosier, Barbara; Fraga, Carlos A. M.; Barreiro, Eliezer J.; Menegatti, Ricardo; Hermans, Emmanuel; Noël, François. Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor. Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 62, p. 1-6, 2015. DOI: 10.1016/j.pnpbp.2015.04.003

26. Silva, Daiany P.B.; Florentino, Iziara F.; Oliveira, Lanussy P.; Lino, Roberta C.; Galdino, Pablinny M.; Menegatti, Ricardo; Costa, Elson A. Anti-nociceptive and anti-inflammatory activities of 4-[(1-phenyl-1H-pyrazol-4-yl) methyl] 1-piperazine carboxylic acid ethyl ester: A new piperazine derivative. Pharmacology, Biochemistry and Behavior, v. 137, p. 86-92, 2015.
DOI:10.1016/j.pbb.2015.08.008

27. Cortez, Alane Pereira; De Ávila, Renato Ivan; Da Cunha, Carla Rosane Mendanha; Santos, Alexandre Pereira; Menegatti, Ricardo; Rezende, Kênnia Rocha; Valadares, Marize Campos. 4-Nerolidylcatechol analogues as promising anticancer agents. European Journal of Pharmacology, v. 765, p. 517-524, 2015.
DOI:10.1016/j.ejphar.2015.08.024

28. Galdino, Pablinny Moreira; De Oliveira, Danillo Ramos; Florentino, Iziara Ferreira; Fajemiroye, James Oluwagbamigbe; Valadares, Marize Campos; De Moura, Soraia Santana; Da Rocha, Fábio Fagundes; De Lima, Thereza Christina Monteiro; Costa, Elson Alves; Menegatti, Ricardo. Involvement of the monoamine system in antidepressant-like properties of 4-(1-phenyl-1h-pyrazol-4-ylmethyl)-piperazine-1-carboxylic acid ethyl ester. Life Sciences, v. 143, p. 187-193, 2015.
DOI: 10.1016/j.lfs.2015.11.009

29. Fonseca, F. N.; Betti, Andresa Heemann; Carvalho, F. C.; Gremiao, M. P. D.; Dimer, F. A.; Guterres, S. S.; Sordi, M. L. T.; Rates, S. M. K.; Pohlmann, A. R.. Mucoadhesive Amphiphilic Methacrylic Copolymer-Functionalized Poly(ε-caprolactone) Nanocapsules for Nose-to-Brain Delivery of Olanzapine. Journal of Biomedical Nanotechnology, v. 11, p. 1472-1481, 2015.
DOI: 10.1166/jbn.2015.2078

30. Dimer, F. A.; Pigatto, M. C.; Antonio, C. B.; Paese, C. S.; Roversi, K.; Pohlmann, A. R.; Burger, M. E.; Rates, S. M. K.; Dalla Costa, Teresa; Guiterres, S. S..Nanoencapsulation Improves Relative Bioavailability and Antipsychotic Effect of Olanzapine in Rats. Journal of Biomedical Nanotechnology, v. 11, p. 1482-1493, 2015.
DOI: 10.1166/jbn.2015.2082

31. Borsoi, M.; Antonio, C. B.; Müller, L. G.; Viana, Alice Fialho; Herzfeldt, V.; Zanotto, C.; Lunardi, P. S.; Nardin, P.; Ravazzolo, A. P.; Rates, S. M. K.; Gonçalves, Carlos Alberto. Repeated forced swimming impairs prepulse inhibition and alters cortical brain-derived neurotrophic factor and hippocampal astroglial parameters in rats. Pharmacology, Biochemistry and Behavior, v. 128, p. 50-61, 2015.
DOI:10.1016/j.pbb.2014.11.012

32. Borsoi, Milene; Antonio, Camila Boque; Viana, Alice Fialho; Nardin, Patricia; Gonçalves, Carlos Alberto; Rates, Stela Maris Kuze. Immobility behavior during the forced swim test correlates with BNDF levels in the frontal cortex, but not with cognitive impairments. Physiology & Behavior, v. 140, p. 79-88, 2015. 
DOI:10.1016/j.physbeh.2014.12.024

33. Müller, Liz; Salles, Luisa; Lins Helena; Feijó, Priscilla; Cassel, Eduardo; Vargas, Rubem; Von Poser, Gilsane; Noël, François; Quintas, Luis; Rates, Stela. Effects of Diene Valepotriates from Valeriana glechomifolia on Na+/K+-ATPase Activity in the Cortex and Hippocampus of Mice. Planta Medica, v. 81, p. 200-207, 2015. 
DOI: 10.1055/s-0034-1396200

34. Valli, Marilia; Betti, Andresa Heemann; Danuello, Amanda; Pivatto, Marcos; Centurião, Fernanda; Antonio, Camila Boque, Rates, Stela Maris Kuze; Bolzani, Vanderlan da Silva. Pyridinic analog of the natural product (−)-spectaline as potential adjuvant for the treatment of central nervous system disorders. Bioorganic & Medicinal Chemistry Letters, v. 25, p. 2247-2250, 2015.
DOI: 10.1016/j.bmcl.2015.02.050

35. Müller, Liz G.; Borsoi, Milene; Stolz, Eveline D.; Herzfeldt, Vivian; Viana, Alice F.; Ravazzolo, Ana Paula; Rates, Stela Maris K.. Diene Valepotriates from Prevent Lipopolysaccharide-Induced Sickness and Depressive-Like Behavior in Mice. Evidence-Based Complementary and Alternative Medicine, v. 2015, p. 1-12, 2015.
DOI: 10.1155/2015/145914.

36. Viana, Alice Fialho; Costentin, Jean; do Rego, Jean-Claude; Rates, Stela Maris Kuze. G-protein activation revealed by [35S]-GTPγS binding assay is involved on the antidepressant-like effect of Hypericum caprifoliatum and Hypericum polyanthemum cyclohexane extracts. Revista Brasileira de Farmacognosia, v. 25, p. 387-394, 2015.
DOI: 10.1016/j.bjp.2015.06.008

37. Andrade, B. M; Baldanza, M. R.; Ribeiro, K. C; Porto, A. Peçanha Ramon; Fortes, F. S; Zapata-Sudo, Gisele; Campos-de-Carvalho, Antonio Carlos; Goldenberg, Regina Coeli; Werneck-de-Castro, João Pedro. Bone marrow mesenchymal cells improve muscle function in a skeletal muscle re-injury model. PLoS One. v. 10, p. e0127561, 2015.
DOI:10.1371/journal.pone.0127561

38. Sudo, Roberto Takashi; Neto, Miguel Lemos; Monteiro, Carlos Eduardo da Silva; Amaral, Rachel Vieiralves; Resende, Ângela C.; Souza, Pergentino Jose C.; Zapata-Sudo, Gisele; Moura, Roberto Soares de. Antinociceptive effects of hydroalcoholic extract from Euterpe oleracea Mart. (Acai) in a rodent model of acute and neuropathic pain. BMC Complementary and Alternative Medicine (Online). v.15, p.208, 2015.
DOI: 10.1186/s12906-015-0724-2

39. Marques, Andre Marques; Pereira, Sharlene Lopes; Paiva, R. A.; Cavalcanti, C. V.; Sudo, Susumu Zapata; Tinoco, I. W., Moreira, D. L., Guimaraes, E. F.; Sudo, Roberto Takashi; Kaplan, Maria Auxiliadora; Zapata-Sudo, Gisele. Hypoglycemic effect of the methanol flower extract of piper claussenianum and the major constituent 2',6'-dihydroxy-4'-methoxychalcone in streptozotocin diabetic rats. Indian Journal of Pharmaceutical Sciences. v.77, p.237-243, 2015.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442476/

40. Moura, Victor José Gonçalves; Alencar, Allan Kardec Nogueira; Calasans-Maia, Jorge de Albuquerque; Silva, Jaqueline Soares; Fraga, Carlos Alberto Manssour; Zapata-Sudo, Gisele, Barreiro, Eliezer J.; Sudo, Roberto Takashi. Novel Agonist of Adenosine Receptor Induces Relaxation of Corpus Cavernosum in Guinea Pigs: An In Vitro and In Vivo Study. Urology v.85, p.1214.e17-1214.e21, 2015
DOI: 10.1016/j.urology.2015.02.006

41. Silva, Tiago Fernandes; Bispo Júnior, Walfrido; Alexandre-Moreira, Magna Suzana; Costa, Fanny Nascimento; Monteiro, Carlos Eduardo da Silva; Furlan Ferreira, Fabio; Barroso, Regina Cely Rodrigues; Noël, François Germain; Sudo, Roberto Takashi, Zapata-Sudo, Gisele, Lima, Lídia Moreira; Barreiro Eliezer J.. Novel orally active analgesic and anti-inflammatory cyclohexyl-n-acylhydrazone derivatives. Molecules (Basel. Online). v. 20, p.3067-3088, 2015.
DOI: 10.3390/molecules20023067

42. Monteiro, Carlos Eduardo da Silva; Nascimento-Júnior, Nailton M.; Trachez, Margarete Manhães; Tesch, Roberta; Mendes, Thaiana Cunha Ferreira; Fraga, Carlos Alberto Manssour; Santanna, Carlos Maurício R.; Zapata-Sudo, Gisele; Barreiro, Eliezer J.; Sudo, Roberto Takashi. Prevention and reversal of morphine-induced tolerance by novel muscarinic receptor agonist in rats with neuropathic pain. Journal of Neurology and Neurophysiology. v.06, p.282, 2015.
DOI: 10.4172/2155-9562.1000282

43. Muzi-Filho, Humberto; Souza, Alessandro M.; Bezerra, Camila G. P.; Boldrini, Leonardo C.; Takiya, Christina Maeda; Oliveira, Felipe L.; Nesi, Renata T.; Valença, Samuel S.; Silva, Ananssa Maíra da Silva; Zapata-Sudo, Gisele; Sudo, Roberto Takashi; Einicker-Lamas, Marcelo; Vieyra, Adalberto; Lara, Lucienne S.; Cunha, Valeria Monti Nascimento. Rats undernourished in utero have altered Ca2+ signaling and reduced fertility in adulthood. Physiological Reports. v.3, p.e12587, 2015.
DOI: 10.14814/phy2.12587

44. Oliveira, Vinícius Rosa; Avila, Mariana Barcellos; Carvalho, Giovanna  Marcella Cavalcante; Azevedo, Sandra Maria F.O.; Lima, Lidia Moreira; Barreiro, Eliezer J.; Carvalho, Alysson Roncally; Zin, Walter Araujo. Investigating the therapeutic effects of LASSBio-596 in an in vivo model of cylindrospermopsin-induced lung injury. Toxicon , v. 94, p. 29-35, 2015.
DOI:10.1016/j.toxicon.2014.12.004

45. Silva, Tiago Fernandes; Bispo Júnior, Walfrido; Allexandre-Moreira, Magna Suzana; Costa, Fanny Nascimento; Monteiro, Carlos; Furlan Ferreira, Fabio; Barroso, Regina Cely Rodrigues; Noël, François; Sudo, Roberto Takashi; Zapata-Sudo, Gisele; Lima, Lídia Moreira; Barreiro, Eliezer J.. Novel Orally Active Analgesic and Anti-Inflammatory Cyclohexyl-N-Acylhydrazone Derivatives. Molecules (Basel. Online), v. 20, p. 3067-3088, 2015.
DOI:10.3390/molecules20023067

46. Moura, Victor J.G.; Alencar, Allan K.N.; Calasans – Maia, Jorge de Albuquerque; da Silva, Jaqueline Soares; Fraga, Carlos A. M.; Zapata-Sudo, Gisele; Barreiro, Eliezer J.; Sudo, Roberto Takashi. Novel Agonist of Adenosine Receptor Induces Relaxation of Corpus Cavernosum in Guinea Pigs: An In Vitro and In Vivo Study. Urology , v. 85, p. 1214.e17-1214.e21, 2015.
DOI:10.1016/j.urology.2015.02.006

47. Cortopassi, W. A.; Ramalho, T. C.; Fraga, Carlos A. M.; Mangas, I. ; Kuca, K. ; Franca, T. C. C.. Bubonic Plague: Historical Aspects and Therapy. Military Medical Science Letters, v. 84, p. 67-75, 2015.
http://mmsl.cz/viCMS/soubory/pdf/MMSL_2015_2_3_WWW.pdf

48. Monteiro, Carlos E. S; Nascimento – Júnior, Nailton M; Trachez, Margarete M; Tesch, Roberta; Mendes, Thaiana C. F; Fraga, Carlos A. M; Santanna, Carlos M. R. De; Zapata- Sudo, Gisele; Barreiro, Eliezer J.; Sudo, Roberto T . Prevention and Reversal of Morphine-Induced Tolerance by Novel Muscarinic Receptor Agonist in Rats with Neuropathic Pain. Journal of Neurology and Neurophysiology, v. 06, p. 1000282, 2015.
DOI: 10.4172/2155-9562.1000282

49. Sato, Juliana Alves Pereira; Costa, Fanny Nascimento; da Rocha, Miguel  Divino; Barreiro, Eliezer J.; Fraga, Carlos Alberto Manssour; Punzo, Francesco; Ferreira, Fabio Furlan. Structural characterization of LASSBio-1289: a new vasoactive N-methyl-N-acylhydrazone derivative. CrystEngComm , v. 17, p. 165-173, 2015.
DOI: 10.1039/C4CE02011A

50. Pompeu, Thais Emanoelle T.; do Monte Fernando Monteiro; Bosier, Barbara; Fraga, Carlos A. M.; Barreiro, Eliezer J.; Menegatti, Ricardo; Hermans, Emmanuel; Noël, François. Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor. Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 62, p. 1-6, 2015.
DOI:10.1016/j.pnpbp.2015.04.003

51. Alves, Marina A.; de Queiroz, Aline C.; Alexandre- Moreira, Magna Suzana; Varela, Javier; Cerecetto, Hugo; González, Mercedes ; Doriguetto, Antonio., Landre, Iara M.; Barreiro, Eliezer J.; Lima, Lídia M.. Design, synthesis and in vitro trypanocidal and leishmanicidal activities of novel semicarbazone derivatives. European Journal of Medicinal Chemistry, v. 100, p. 24-33, 2015.
DOI:10.1016/j.ejmech.2015.05.046.

52. Costa, Fanny Nascimento; da Silva, Tiago Fernandes; Miguez, Eduardo; Barroso, Regina Cely; Braz, Delson; Barreiro, Eliezer J.; Lima, Lídia Moreira; Punzo, Francesco; Ferreira, Fabio Furlan.. Structural features evolution - from fluids to solid phase - and crystal morphology study of LASSBio-1601: a cyclohexyl-N-acylhydrazone derivative. RSC Advances: an international journal to further the chemical sciences, v. 5, p. 39889-39898, 2015.
DOI: 10.1039/C5RA02696B

53. Thota, Sreekanth; Vallala, Srujana; Yerra, Rajeshwar; Barreiro, Eliezer J. . Design, synthesis, characterization, cytotoxic and structure activity relationships of novel Ru(II) complexes. Chinese Chemical Letters, v. 26, p. 721-726, 2015.
DOI: 10.1016/j.cclet.2015.03.011

54. Tabrizi, Mojgan; Baraldi, Pier; Baraldi, Stefania; Prencipe, Filippo; Preti, Delia; Saponaro, Giulia; Romagnoli, Romeo; Gessi, Stefania; Merighi, Stefania; Stefanelli, Angela; Fazzi, Debora; Borea, Pier; Maia, Rodolfo; Romero, Nelilma; Fraga, Carlos; Barreiro, Eliezer J. Synthesis and Biological Evaluation of Pyrazolo[3,4-b]pyridin-4-ones as a New Class of Topoisomerase II Inhibitors. Medicinal Chemistry , v. 11, p. 342-353, 2015.
DOI: 10.2174/1573406411666141210141317

55. Marques, Emiliana B.; Motta, Nádia A. V.; Kummerle, Arthur E.; Fraga, Carlos A. M.; Barreiro, Eliezer J.; Brito, Fernanda C.F.; Scaramello, Christianne B. V.. In vivo effect of LASSBio-785, a lipid-lowering and anti-inflammatory agent, on cardiac Ca2+-ATPases from hypercholesterolemic rats. International Journal of Cardiology , v. 201, p. 282-284, 2015.
DOI: 10.1016/j.ijcard.2015.08.091

56. Lima Toccafondo Vieira, Manuela; Lídia Moreira Lima; Barreiro, Eliezer J.; Tagliati, Carlos Alberto. Investigation of Low Bioavailability Using Physiologically Based Pharmacokinetic Modeling: A Case Example (Lassbio-596). British Journal of Applied Science & Technology, v.5, p. 613-620, 2015.
DOI: 10.9734/BJAST/2015/13527


57. Piló, Elisa D.L.; Recio-Despaigne, Angel A.; Da Silva, Jeferson G.; Ferreira, Isabella P.; Takahashi, Jaqueline  A.; Beraldo, Heloisa . Effect of coordination to antimony(III) on the antifungal activity of 2- acetylpyridine- and 2-benzoylpyridine-derived hydrazones. Polyhedron, v. 97, p. 30-38, 2015.
Doi:10.1016/j.poly.2015.05.004
 

58. Tamayo Lopes, Lenka ; L. R. Gouvea; A.C. Sousa; R.M. Albuquerque; S.F. Teixeira; R.A. Azevedo; Louro, S.; A.K. Ferreira; Heloisa Beraldo. Copper(II) complexes with naringenin and hesperetin: cytotoxic activity against A 549 human lung adenocarcinoma cells and investigation on the mode of action. BioMetals (Oxford), v. 1, p. 1-14, 2015.
Doi: 10.1007/s10534-015-9894-0


 59. R. P. Vieira, J. R. Thompson, H. Beraldo and T. Storr. Partial conversion of thio­amide into nitrile in a copper(II) complex of 2,6-di­acetyl­pyridine bis­(thio­semicarbazone), a drug prototype for Alzheimer's disease. Acta. Cryst C., v 71, part 6, 2015.
Doi: 10.1107/S205322961500813X