PUBLICAÇÕES INCT 2016

Publicações Internacionais



Fumian, Milla Machado; Da Motta, Nadia Alice Vieira; Maia Rodolfo; Fraga, Carlos Alberto Manssour; Barreiro, Eliezer Jesus; Ferreira de Brito, Fernanda Carla. LASSBio-1425, an analog of thalidomide, decreases triglyceride and increases HDL cholesterol levels by inhibition of TNF-α production. International Journal of Cardiology (Print), v. 202, p. 497-499, 2016.
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Dias, Luiz C.; Vieira, Adriano S.; Barreiro, Eliezer J.. The total synthesis of calcium atorvastatin. Organic & Biomolecular Chemistry, v. 14, p. 2291-2296, 2016.
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Silva, Johnatas Dutra; de Oliveira, Gisele Pena; Samary, Cynthia dos Santos; Araujo, Carla Cristina; Padilha, Gisele de Araujo; E Silva Filho, Fernando Costa; Da Silva, Rosilane Taveira; Eincker- Lamas, Marcelo; Morales, Marcelo Marcos; Capelozzi, Vera Luiza; Da Silva, Vanessa Martins; Lima, Lídia Moreira; Barreiro, Eliezer Jesus; Diaz, Bruno Lourenço; Pelosi, Paolo; Silva, Pedro Leme; Garcia, Cristiane Souza Nascimento Baez; Rocco, Patricia Reiken Macedo. Respiratory and Systemic Effects of LASSBio596 Plus Surfactant in Experimental Acute Respiratory Distress Syndrome. Cellular Physiology and Biochemistry, v. 38, p. 821-835, 2016.
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 Betti, A. H.; Stolz, E. D. ; Barros, F. M.; Müller, L. G. ; Von Poser, G. L. ; Rego, J.L. ; Rego, J. C.; Vaudry, D.; Rates, S. M. K. . Dimeric Phloroglucinol Derivatives but Not Benzopyrans from Hypericum Species Have No Toxicity on Cerebellar Primary Neurons. International Journal of Pharmacognosy and Phytochemical Research, v. 8, p. 446-452, 2016.

Bridi, Henrique; Ccana-Ccapatinta, Gari V.; Stolz, Eveline D.; Meirelles, Gabriela C.; Bordignon, Sérgio A.L. ; Kuze Rates, Stela Maris; Poser, G. L. V. Dimeric acylphloroglucinols from Hypericum austrobrasiliense exhibiting antinociceptive activity in mice. Phytochemistry, v. 122, p. 178-183, 2016.
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Stolz, Eveline Dischkaln; da Costa, Paola Fontoura; Medeiros, Liciane Fernandes; Souza, Andressa; Battastini, Ana Maria Oliveira; von Poser, Gilsane Lino; Bonan, Carla; Torres, Iraci L. S.; Rates, Stela Maris Kuze. Uliginosin B, a Possible New Analgesic Drug, Acts by Modulating the Adenosinergic System. Evidence-Based Complementary and Alternative Medicine (Print), v. 2016, p. 1-8, 2016.
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Antonio, Camila B.; Betti, Andresa H.; Herzfeldt, Vivian; Barreiro, Eliezer J.; Fraga, Carlos A.M.; Rates, Stela M.K. . LASSBio-579, a prototype antipsychotic drug, and clozapine are effective in novel object recognition task, a recognition memory model. Behavioural Pharmacology, v. 27, p. 339-349, 2016.
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Noel F. & Monteiro do Monte, F. Na+-shift binding assay for estimation of the intrinsic efficacy of ligands at the A2A adenosine receptor. Journal of Pharmacological and Toxicological Methods.
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Betti AH, Antonio CB, Pompeu TET, Thaise Martins TS, Herzfeldt V, Stolz ED, Fraga CAM, Barreiro EJ, Noël F, Rates SMK. LASSBio-1422: a new molecular scaffold with efficacy in animal models of schizophrenia and disorders of attention and cognition. Behavioural Pharmacology.
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Noël F, Nascimento-Viana J, Romeiro LA, Silva R, Lemes L, Oliveira A, Giorno T, Fernandes P, Silva CLM. ADME studies and preliminary safety pharmacology of LDT5, a lead compound for the treatment of Benign Prostatic Hyperplasia. Brazilian Journal of Biological and Medical Research.
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Alves, M. A.; Nirma, C.; Moreira, M. M.; Soares, R. O. ; Pascutti, P. G.; Noël, F.; Costa, P. R. R.; Sant'Anna, C. M. R.; Barreiro, E. J.; Lima, L. M. ; Tinoco, L. W. . Non-competitive inhibitor of nucleoside hydrolase from Leishmania donovani identified by fragment-based drug discovery. RSC Advances: an international journal to further the chemical sciences, v. 6, p. 87738-87744, 2016.
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Perera Córdova WH, Leitão SG, Cunha-Filho G, Bosch RA, Alonso IP, Pereda-Miranda R, Gervou R, Touza NA, Quintas LE, Noël F. Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): inhibition of human kidney Na+/K+-ATPase activity.. Toxicon. 110 (2016) 27-34.
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Nascimento-Viana, J. B.; Carvalho, A. R.; Nasciutti, L. E. ; Alcantara-Hernandez, R.; Chagas-Silva, F.; de Souza, P. A. R.; Romeiro, L. A.; Garcia-sainz, J. A.; Noel, F.; Silva, C. L. M.. New multi-target antagonists of  1A-,  1D-adrenoceptors and 5-HT1A receptors reduce human hyperplastic prostate cell growth and the increase of intraurethral pressure. The Journal of Pharmacology and Experimental Therapeutics (Online), v. 356, p. 212-222, 2016.
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Chaves, Otávio Augusto; da Silva, Veridiana A.; Sant'Anna, Carlos Maurício R.; Ferreira, Aurélio B.B.; Ribeiro, Tereza Auxiliadora N.; de Carvalho, Mário G.; Cesarin-Sobrinho, Dari; Netto-Ferreira, José Carlos. Binding studies of lophirone B with bovine serum albumin (BSA): Combination of spectroscopic and molecular docking techniques. Journal of Molecular Structure (Print). , v.1128, p.606 - 611, 2016.
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Rodrigues, Daniel A.; Ferreira-silva, Guilherme À.; Ferreira, Ana C. S.; Fernandes, Renan A.; Kwee, Jolie K.; Sant’Anna, Carlos M. R.; Ionta, Marisa; Fraga, Carlos A. M.
Design, Synthesis, and Pharmacological Evaluation of Novel -Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors. Journal of Medicinal Chemistry. , v.59, p.655 - 670, 2016.
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De Barros, Leonardo Santos; Chaves, Otávio Augusto; Schaeffer, Edgar; Sant’Anna, Carlos Mauricio R.; Ferreira, Aurélio B.B.; Cesarin-Sobrinho, Dari; da Silva, Francisco Assis; Netto-Ferreira, José Carlos. Evaluating the interaction between di-fluorinated chalcones and plasmatic albumin. Journal of Fluorine Chemistry. , v.190, p.81 - 88, 2016.
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Chaves, Otávio A.; Jesus, Catarina S.H.; Cruz, Pedro F.; Sant'Anna, Carlos M.R.; Brito, Rui M.M.; Serpa, Carlos. Evaluation by fluorescence, STD-NMR, docking and semi-empirical calculations of the o-NBA photo-acid interaction with BSA. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy (Print). , v.169, p.175 - 181, 2016.
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Sueth-Santiago, Vitor; Moraes, Julliane de B. B.; Sobral Alves, Eliomara Sousa; Vannier-Santos, Marcos André; Freire-de-Lima, Célio G.; Castro, Rosane N.; Mendes-Silva, Gustavo Peron; Del Cistia, Catarina de Nigris; Magalhães, Luma Godoy; Andricopulo, Adriano Defini; Sant´Anna, Carlos Mauricio R.; Decoté-Ricardo, Debora; Freire de Lima, Marco Edilson. The Effectiveness of Natural Diarylheptanoids against Trypanosoma cruzi: Cytotoxicity, Ultrastructural Alterations and Molecular Modeling Studies. Plos One. , v.11, p.e0162926 - , 2016.
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Wang, Hao; Alencar, Allan; Lin, Marina; Sun, Xuming; Sudo, Roberto T.; Zapata-Sudo, Gisele; Lowe, Dawn A.; Groban, Leanne. Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344Brown Norway rats. Biochemical and Biophysical Research Communications, v.475, p.81 - 86, 2016.
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Alencar, Allan K.N.; da Silva, Jaqueline S.; Lin, M.; Silva. A.M.S.; Sun, X.; Ferrario, C. M.; Cheng, C.; Sudo, Roberto T.; Zapata-Sudo, G.; Wang, H.; Groban, L. Effect of Age, Estrogen Status, and Late-Life GPER Activation on Cardiac Structure and Function in the Fischer344×Brown Norway Female Rat. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 2016.
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Wang, Hao; da Silva, Jaqueline; Alencar, Allan; Zapata-Sudo, Gisele; Lin, Marina S.; Sun, Xuming; Ahmad, Sarfaraz; Ferrario, Carlos M.; Groban, Leanne. Mast Cell Inhibition Attenuates Cardiac Remodeling and Diastolic Dysfunction in Middle-aged, Ovariectomized Fischer344×Brown Norway Rats. Journal of Cardiovascular Pharmacology, v.68, p.1 - 57, 2016.
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Zapata-Sudo, Gisele; Nunes, I. K.; Araujo, J. S. C.; da Silva J S; Trachez, M.M.; Silva, Tiago Fernandes; Costa, F. P.; Sudo, R.T.; Barreiro, Eliezer J.; Lima, Lidia M.. Synthesis, Solubility, Plasma Stability and Pharmacological Evaluation of Novel Sulfonylhydrazones Designed as Anti-diabetes Agents. Drug Design, Development and Therapy, v. 10, p. 2869-2879, 2016.
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Montes, G. C.; Hammes, N.; Rocha, M. D.; Montagnoli, T. L.; Fraga, Carlos Alberto M; Barreiro, Eliezer J.; Sudo, Roberto T.; Zapata-Sudo, Gisele. Treatment with Adenosine Receptor Agonist Ameliorates Pain Induced by Acute and Chronic Inflammation. The Journal of Pharmacology and Experimental Therapeutics, v.358, p.315 - 323, 2016.
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Luciana B.P. Sâmia ; Gabrieli L. Parrilha ; da Silva, J. G.; Ramos, Jonas P.; Souza-Fagundes, Elaine M.; Castelli, S. ; Vutey Venn ; Alessandro Desideri ; Heloisa Beraldo . Metal complexes of 3-(4-bromophenyl)-1-pyridin-2-ylprop-2-en-1-one thiosemicarbazone: cytotoxic activity and investigation on the mode of action of the gold(III) complex. BioMetals 29 (2016) 515-526.
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Ferreira, Isabella P.; Piló, Elisa D.L.; Recio-Despaigne, Angel A.; Da Silva, Jeferson G.; Ramos, Jonas P.; Marques, Lucas B.; Prazeres, Pedro H.D.M.; Takahashi, Jacqueline A.; Souza-Fagundes, Elaine M.; ROCHA, WILLIAN; Beraldo, Heloisa. Bismuth(III) complexes with 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones: antimicrobial and cytotoxic activities and effects on the clonogenic survival of human solid tumor cells. Bioorganic & Medicinal Chemistry 24 (2016) 2988-2998, 2016.
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Garcia, Camila Vargas; Parrilha, Gabrieli; Rodrigues, Bernardo; Teixeira, Sarah Fernandes; Azevedo, Ricardo; Ferreira, Adilson Kleber; Beraldo, Heloisa. Tricarbonylrhenium(I) complexes with 2-acetylpyridine-derived hydrazones are cytotoxic to NCI-H460 human large cell lung cancer. New Journal of Chemistry 40 (2016) 7379-7387.
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Vutey, Venn; Castell I, Silvia; D'Annessa, Ilda; Sâmia, Luciana B.P.; Souza-Fagundes, Elaine M.; Beraldo, Heloisa; Desideri, Alessandro. Human topoisomerase IB is a target of a thiosemicarbazone copper(II) complex. Archives of Biochemistry and Biophysics 606 (2016) 34-40.
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Pereira, R. M.; Silva, G. A. F.; Pivatto, M.; Santos, L. A.; Bolzani, Vanderlan da Silva; Paula, D. A. C.; Oliveira, J. C.; Viegas Jr., C.; Ionta, M.. Alkaloids derived from flowers of Senna spectabilis, (−)-cassine and (−)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression. Toxicology in Vitro, v. 31, p. 86-92, 2016.
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Castro, A. T.; Castro, A. P.; Silva, M. S.; Souza, I. M. M.; Souza, R. L. M.; Paula, D. A. C.; Leomil-Coelho, L. F.; Bolzani, Vanderlan da Silva; Pivatto, Marcos; Viegas Jr, C.; Marques, Marcos José. In vitro Evaluation of the Schistosomicidal Effect of the Extracts, Fractions and major 3-Hydroxy-2,6-Dialkyl-Substituted Piperidine Alkaloids from the Flowers of Senna spectabilis (Fabaceae). Bioorganic & Medicinal Chemistry Letters (Print), p. 4197-4204, 2016.
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Gontijo, V. S.; dos Santos, M.H.; Viegas Jr., C.. Biological and Chemical Aspects of Natural Biflavonoids from Plants: a Brief Review. Mini-Reviews in Medical Chemistry, 2016.

Guedes, Isabella A.; Freitas, Rosana H. C. N.; Cordeiro, Natália M.; Nascimento, Thaís S. do; Valerio, Tayna S.; Fernandes, Patrícia D.; Dardenne, Laurent E. ; Fraga, Carlos A. M.. LASSBio-1829 Hydrochloride: Development of a New Orally Active N -Acylhydrazone IKK2 Inhibitor with 
Anti-inflammatory Properties. Chemmedchem (Print), v. 11, p. 234-244, 
2016.
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Ramundo, Mariana Severo; Beltrame, Cristiana Ossaille; Botelho, Ana Maria Nunes; Coelho, Leonardo Rocchetto; Silva-Carvalho, Maria Cicera; Ferreira-Carvalho, Bernadete Teixeira; Nicolás, Marisa Fabiana; Guedes, Isabella Alvim; Dardenne, Laurent Emmanuel; Ogara, James; Figueiredo, Agnes Marie Sá. A unique SaeS allele overrides cell-density dependent expression of saeR and lukSF-PV in the ST30-SCCmecIV lineage of CA-MRSA. International Journal of Medical Microbiology (Print), v. 306, p. 367-380, 2016.
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Ceschi, Marco Antonio; da Costa, Jessie Sobieski; Lopes, João Paulo Bizarro; Câmara, Viktor Saraiva; Campo, Leandra Franciscato; Borges, Antonio César de Amorim; Gonçalves, Carlos Alberto Saraiva; de Souza, Daniela Fraga; Konrath, Eduardo Luis; Karl, Ana Luiza Martins;  Guedes, Isabella Alvim; Dardenne, Laurent Emmanuel. Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S100B secretion and a molecular modeling approach. European Journal of Medicinal Chemistry, v. 121, p. 758-772, 2016.
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Bassi GS, do C Malvar D, Cunha TM, Cunha FQ, Kanashiro A. Spinal GABA-B receptor modulates neutrophil recruitment to the knee joint in zymosan-induced arthritis. Naunyn Schmiedebergs Arch Pharmacol. 2016 Aug;389(8):851-61
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Carlos D, Yaochite JN, Rocha FA, Toso VD, Malmegrim KC, Ramos SG, Jamur MC, Oliver C, Camara NO, Andrade MV, Cunha FQ, da Silva JS. Mast cells control insulitis and increase Treg cells to confer protection against STZ-induced type 1 diabetes in mice. Eur J Immunol. 2015 Oct;45(10):2873-85.
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Czaikoski PG, Mota JM, Nascimento DC, Sônego F, Castanheira FV, Melo PH, Scortegagna GT, Silva RL, Barroso-Sousa R, Souto FO, Pazin-Filho A, Figueiredo F, Alves-Filho JC, Cunha FQ. Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis. PLoS One. 2016 Feb 5;11(2):e0148142
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da Silva Dias IC, Carabelli B, Ishii DK, de Morais H, de Carvalho MC, Rizzo de Souza LE, Zanata SM, Brandão ML, Cunha TM, Ferraz AC, Cunha JM, Zanoveli JM. Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes. Mol Neurobiol. 2015 Dec 15. In Press.
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de Molon RS, Hsu C, Bezouglaia O, Dry SM, Pirih FQ, Soundia A, Cunha FQ, Cirelli JA, Aghaloo TL, Tetradis S. Rheumatoid Arthritis Exacerbates the Severity of Osteonecrosis of the Jaws (ONJ) in Mice. A Randomized, Prospective, Controlled Animal Study. J Bone Miner Res. 2016 Mar 7.
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Fattori V, Pinho-Ribeiro FA, Borghi SM, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr. Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation. Inflamm Res. 2015 Dec;64(12):993-1003.
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Franca RF, Costa RS, Silva JR, Peres RS, Mendonça LR, Colón DF, Alves-Filho JC, Cunha FQ. IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system. J Neuroinflammation. 2016 Jun 22;13(1):159.
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Franca, RFO; Vieira, SM; Talbot, J; Peres, RS; Pinto, LG; Zamboni, DS; Louzada-Junior, P; Cunha, FQ; Cunha, TM. Expression and activity of NOD1 and NOD2 / RIPK2 signalling in mononuclear cells from patients with rheumatoid arthritis. Scandinavian Journal of Rheumatology (Trykt Utg.), v. 45, p. 8-12, 2016.
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Franchin M, Cólon DF, Castanheira FV, da Cunha MG, Bueno-Silva B, Alencar SM, Cunha TM, Rosalen PL. Vestitol Isolated from Brazilian Red Propolis Inhibits Neutrophils Migration in the Inflammatory Process: Elucidation of the Mechanism of Action. J Nat Prod. 2016 Mar 3. In Press.
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Franchin M, Rosalen PL, da Cunha MG, Silva RL, Colón DF, Bassi GS, de Alencar SM, Ikegaki M, Alves-Filho JC, Cunha FQ, Beutler JA, Cunha TM. Cinnamoyloxy-mammeisin Isolated from Geopropolis Attenuates Inflammatory Process by Inhibiting Cytokine Production: Involvement of MAPK, AP-1, and NF-κB. J Nat Prod. 2016 Jul 22;79(7):1828-33.
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Huang L, Ou R, Rabelo de Souza G, Cunha TM, Lemos H, Mohamed E, Li L, Pacholczyk G, Randall J, Munn DH, Mellor AL. Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase. PLoS Pathog. 2016 May 11;12(5):e1005615.
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Kanashiro A, Talbot J, Peres RS, Pinto LG, Bassi GS, Cunha TM, de Q Cunha F. Neutrophil Recruitment and Articular Hyperalgesia in Antigen-Induced Arthritis is Modulated by the Cholinergic Anti-Inflammatory Pathway. Basic Clin Pharmacol Toxicol. 2016 Apr 21. In Press.
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Leite CA, Alencar VT, Melo DL, Mota JM, Melo PH, Mourão LT, Wong DV, Magalhães PJ, Santos AA, Brito GA, Lima-Júnior RC, Cunha FQ, Ribeiro RA. Target Inhibition of IL-1 Receptor Prevents Ifosfamide Induced Hemorrhagic Cystitis in Mice. J Urol. 2015 Dec;194(6):1777-86.
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Longhi-Balbinot DT, Rossaneis AC, Pinho-Ribeiro FA, Bertozzi MM, Cunha FQ, Alves-Filho JC, Cunha TM, Peron JP, Miranda KM, Casagrande R, Verri WA Jr. The nitroxyl donor, Angeli's salt, reduces chronic constriction injury-induced neuropathic pain. Chem Biol Interact. 2016 Jun 7;256:1-8. In Press.
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Lopes AH, Brandolini L, Aramini A, Bianchini G, Silva RL, Zaperlon AC, Verri WA Jr, Alves-Filho JC, Cunha FQ, Teixeira MM, Allegretti M, Cunha TM. DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain. Pharmacol Res. 2016 Jan;103:69-79.
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Molinaro R, Pecli C, Guilherme RF, Alves-Filho JC, Cunha FQ, Canetti C, Kunkel SL, Bozza MT, Benjamim CF. CCR4 Controls the Suppressive Effects of Regulatory T Cells on Early and Late Events during Severe Sepsis. PLoS One. 2015 Jul 21;10(7):e0133227.
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Mota JM, Leite CA, Souza LE, Melo PH, Nascimento DC, de Deus Wagatsuma VM, Temporal J, Figueiredo F, Noushmehr H, Alves-Filho JC, Cunha FQ, Rego EM. Post-sepsis state induces tumor-associated macrophage accumulation through CXCR4/CXCL12 and favors tumor progression in mice. Cancer Immunol Res. 2016 Jan 27. pii: canimm.0170.2015. In Press.
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Peres RS, Menezes GB, Teixeira MM, Cunha FQ. Pharmacological opportunities to control inflammatory diseases through inhibition of the leukocyte recruitment. Pharmacol Res. 2016 Jan 22. pii: S1043-6618(16)00021-9. In Press.
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Pinho-Ribeiro FA, Fattori V, Zarpelon AC, Borghi SM, Staurengo-Ferrari L, Carvalho TT, Alves-Filho JC, Cunha FQ, Cunha TM, Casagrande R, Verri WA Jr. Pyrrolidine dithiocarbamate inhibits superoxide anion-induced pain and inflammation in the paw skin and spinal cord by targeting NF-κB and oxidative stress. Inflammopharmacology. 2016 Jun;24(2-3):97-107.
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Pinho-Ribeiro FA, Zarpelon AC, Mizokami SS, Borghi SM, Bordignon J, Silva RL, Cunha TM, Alves-Filho JC, Cunha FQ, Casagrande R, Verri WA Jr. The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-κB activation. J Nutr Biochem. 2016 Jul;33:8-14.
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Pinto LG, Talbot J, Peres RS, Franca RF, Ferreira SH, Ryffel B, Aves-Filho JC, Figueiredo F, Cunha TM, Cunha FQ. Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production. Arthritis Res Ther. 2015 Sep 2;17:235.
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Pucca MB, Cerni FA, Cordeiro FA, Peigneur S, Cunha TM, Tytgat J, Arantes EC. Ts8 scorpion toxin inhibits the Kv4.2 channel and produces nociception in vivo. Toxicon. 2016 Jun 23;119:244-252. doi: 10.1016/j.toxicon.2016.06.014. In Press.
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Quadros AU, Cunha TM. C5a and pain development: An old molecule, a new target. Pharmacol Res. 2016 Feb 11. pii: S1043-6618(16)00041-4. In Press.
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Quadros AU, Pinto LG, Fonseca MM, Kusuda R, Cunha FQ, Cunha TM. Dynamic weight bearing is an efficient and predictable method for evaluation of arthritic nociception and its pathophysiological mechanisms in mice. Sci Rep. 2015 Oct 29;5:14648.
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Sacramento L, Trevelin SC, Nascimento MS, Lima-Jùnior DS, Costa DL, Almeida RP, Cunha FQ, Silva JS, Carregaro V. Toll-Like Receptor 9 Signaling in Dendritic Cells Regulates Neutrophil Recruitment to Inflammatory Foci following Leishmania infantum Infection. Infect Immun. 2015 Dec;83(12):4604-16.
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Santa-Cecília FV, Socias B, Ouidja MO, Sepulveda-Diaz JE, Acuña L, Silva RL, Michel PP, Del-Bel E, Cunha TM, Raisman-Vozari R. Doxycycline Suppresses Microglial Activation by Inhibiting the p38 MAPK and NF-kB Signaling Pathways. Neurotox Res. 2016 Jan 8. In Press.
[DOI]

Sant'Anna MB, Kusuda R, Bozzo TA, Bassi GS, Alves-Filho JC, Cunha FQ, Ferreira SH, Souza GR, Cunha TM. Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. Sci Rep. 2016 May 27;6:26955.
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Santos SS, Carmo AM, Brunialti MK, Machado FR, Azevedo LC, Assunção M, Trevelin SC, Cunha FQ, Salomao R. Modulation of monocytes in septic patients: preserved phagocytic activity, increased ROS and NO generation, and decreased production of inflammatory cytokines. Intensive Care Med Exp. 2016 Dec;4(1):5.
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Serafim KG, Navarro SA, Zarpelon AC, Pinho-Ribeiro FA, Fattori V, Cunha TM, Alves-Filho JC, Cunha FQ, Casagrande R, Verri WA Jr. Bosentan, a mixed endothelin receptor antagonist, inhibits superoxide anion-induced pain and inflammation in mice. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388(11):1211-21.
[DOI]

Silva RL, Castanheira FV, Figueiredo JG, Bassi GS, Ferreira SH, Cunha FQ, Cunha TM, Kanashiro A. Pharmacological Beta-Adrenergic Receptor Activation Attenuates Neutrophil Recruitment by a Mechanism Dependent on Nicotinic Receptor and the Spleen. Inflammation. 2016 Aug;39(4):1405-13.
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Sônego F, Castanheira FV, Ferreira RG, Kanashiro A, Leite CA, Nascimento DC, Colón DF, Borges Vde F, Alves-Filho JC, Cunha FQ. Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious. Front Immunol. 2016 Apr 26;7:155.
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Vaz ER, Fujimura PT, Araujo GR, da Silva CA, Silva RL, Cunha TM, Lopes-Ferreira M, Lima C, Ferreira MJ, Cunha-Junior JP, Taketomi EA, Goulart LR, Ueira-Vieira C. A Short Peptide That Mimics the Binding Domain of TGF-β1 Presents Potent Anti-Inflammatory Activity. PLoS One. 2015 Aug 27;10(8):e0136116.
[DOI]

Veras FP, Peres RS, Saraiva AL, Pinto LG, Louzada-Junior P, Cunha TM, Paschoal JA, Cunha FQ, Alves-Filho JC. Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway. Sci Rep. 2015 Oct 19;5:15171.
[DOI]

Wong DV, Lima-Júnior RC, Carvalho CB, Borges VF, Wanderley CW, Bem AX, Leite CA, Teixeira MA, Batista GL, Silva RL, Cunha TM, Brito GA, Almeida PR, Cunha FQ, Ribeiro RA. The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis. PLoS One. 2015 Oct 6;10(10):e0139985.
[DOI]

Yamacita-Borin FY, Zarpelon AC, Pinho-Ribeiro FA, Fattori V, Alves-Filho JC, Cunha FQ, Cunha TM, Casagrande R, Verri WA Jr. Superoxide anion-induced pain and inflammation depends on TNFα/TNFR1 signaling in mice. Neurosci Lett. 2015 Sep 25;605:53-8.
[DOI]

Zarpelon AC, Rodrigues FC, Lopes AH, Souza GR, Carvalho TT, Pinto LG, Xu D, Ferreira SH, Alves-Filho JC, McInnes IB, Ryffel B, Quesniaux VF, Reverchon F, Mortaud S, Menuet A, Liew FY, Cunha FQ, Cunha TM, Verri WA Jr. Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain. FASEB J. 2016 Jan;30(1):54-65.
[DOI]

Antunes, A. M. S.; Guerrante, R.DI S.; Ávila, J. P.C.; Mendes, F. M.L. ; Fierro, I. M. Case Study of Patents Related to Captopril, Squibb’s First Blockbuster. Expert Opinion on Therapeutic Patents, v. 26, p. 13543776.2016.1227321, 2016.
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Kropf, M.; Antunes, A. M. S. Analysis of Trends in Orthopedic Prosthetics. International Journal of Biotechnology and Bioengineering, v. 1, p. 1, 2016.

Ranke, N. L. V.; Fierro, I.; Antunes, A. M. S. Trends in Biotechnological Drugs for Cancer Treatment. Recent Patents on Anti-Cancer Drug Discovery, v. 11, p. 112-120, 2016.

Torres, Rafael Carvalho ; Magalhães, Nathalia Santos ; e Silva, Patrícia M.R. ; Martins, Marco A. ; Carvalho, Vinicius F. . Activation of PPAR-γ reduces HPA axis activity in diabetic rats by up-regulating PI3K expression. Experimental and Molecular Pathology (Print), v. 101, p. 290-301, 2016.
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Nunes, Isabelle Karine da Costa ; de Souza, Everton Tenório ; Cardozo, Suzana Vanessa S. ; Carvalho, Vinicius de Frias ; Romeiro, Nelilma Correia ; Silva, Patrícia Machado Rodrigues e ; Martins, Marco Aurélio ; Barreiro, Eliezer J. ; Lima, Lídia Moreira . Synthesis, Pharmacological Profile and Docking Studies of New Sulfonamides Designed as Phosphodiesterase-4 Inhibitors. Plos One, v. 11, p. e0162895-26, 2016.
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Ferreira, Tatiana Paula Teixeira ; Mariano, Lívia Lacerda ; Ghilosso-Bortolini, Roberta ; Arantes, Ana Carolina Santos de ; Fernandes, Andrey Junior ; Berni, Michelle ; Cecchinato, Valentina ; Uguccioni, Mariagrazia ; Maj, Roberto ; Barberis, Alcide ; Silva, Patricia Machado RodrigueS E ; Martins, Marco Aurélio . Potential of PEGylated Toll-Like Receptor 7 Ligands for Controlling Inflammation and Functional Changes in Mouse Models of Asthma and Silicosis. Frontiers in Immunology (Online), v. 7, p. 1, 2016.
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Alberto, A. V. P. ; Faria, Robson Xavier ; Menezes, J. R. L. ; Surrage, A. ; Rocha, N.C. ; Ferreira, L.G.B. ; Frutuoso, V.S. ; Martins, M. A. ; Alves, Luiz Anastácio . Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation. Plos One, v. 11, p. e0145392, 2016.
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Silva, Adriana L.; Magalhaes, R. ; Branco, V. ; Silva, J. ; Cruz, F. ; Marques, P. ; Ferreira, T. P. T. ; Morales, M. ; Martins, M. A. ; Rocco, P. R. M. . The tyrosine kinase inhibitor dasatinib reduces lung inflammation and remodelling in experimental allergic asthma. British Journal of Pharmacology, v. 173, p. 1236-1247, 2016.
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Serra, M. F.; Neves, Josiane Sabbadine; Couto, Gina C. ; Cotias, A. C. ; Pao, C. R. R. ; Olsen, P. C ; de Carvalho, Katharinne Ingrid Moraes ; Anjos-Valotta, Edna A. ; Faria, Robson Xavier ; da Costa, Jorge C.S. ; Cordeiro, Renato S.B. ; e Silva, Patrícia M.R. ; Martins, M A . JM25-1, a Lidocaine Analog Combining Airway Relaxant and Antiinflammatory Properties. Anesthesiology (Philadelphia), v. 124, p. 109-120, 2016.
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Rodrigues, Daniel; Thota, Sreekanth; Fraga, Carlos. Beyond the Selective Inhibition of Histone Deacetylase 6. Mini-Reviews in Medical Chemistry, v. 16, p. 1175-1184, 2016.
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Ferreira, Thayssa; Fraga, Carlos. Understanding the Structural Basis of ALDH-2 Inhibition by Molecular Docking. Medicinal Chemistry (Hilversum), v. 12, p. 506-512, 2016.
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Cordeiro, Natália M.; Freitas, Rosana H. C. N.; Fraga, Carlos A. M.; Fernandes, Patricia D.. Discovery of Novel Orally Active Tetrahydro-Naphthyl-N-Acylhydrazones with In Vivo Anti-TNF-α Effect and Remarkable Anti-Inflammatory Properties. Plos One, v. 11, p. e0156271, 2016.
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Senger, Mario R.; Fraga, Carlos A.M. ; Dantas, Rafael F. ; Silva, Floriano P. . Filtering promiscuous compounds in early drug discovery: is it a good idea?. Drug Discovery Today, v. 21, p. 868-872, 2016.
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Elizondo-Jimenez, Silvia; Moreno-Herrera, Antonio; Reyes-Olivares, Rogelio; Dorantes-Gonzalez, Edith; Nogueda-Torres, Benjamín; de Oliveira, Eduardo; Romeiro, Nelilma; Lima, Lidia; Palos, Isidro; Rivera, Gildardo . Synthesis, Biological Evaluation and Molecular Docking of New Benzenesulfonylhydrazone as Potential Anti-Trypanosoma Cruzi Agents. Medicinal Chemistry (Hilversum), v. 12, p. 1-1, 2016.
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Moraes, Barbra Katyuschya Sanches; Bajerski, Lisiane; Parisotto, Alcides; Silva, Carlos Eduardo da Rosa; Alves, Marina Amaral; Barreiro, Eliezer de Jesus; Freddo, Rodrigo José; Dalla Costa, Teresa; Lima, Lídia Moreira; Haas, Sandra Elisa. Simple HPLC-UV for the quantification of a new leishmanicidal candidate ( E )-1-4(trifluoromethyl) benzylidene)-5-(2-4-dichlorozoyl) carbonylhydrazine (LASSBio-1736) in rat plasma for pharmacokinetics assessment. BMC. Biomedical Chromatography, v. 30, p. 1029-1035, 2016.
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